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Mouse bone marrow-derived IL-3 dependent mast cells and autonomous sublines produce IL-6.

Immunology 67, 408-413 (1989)
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This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe.
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Publication type Article: Journal article
Document type Scientific Article
Language
Publication Year 1989
HGF-reported in Year 1989
ISSN (print) / ISBN 0019-2805
e-ISSN 1365-2567
Journal Immunology
Quellenangaben Volume: 67, Issue: 3, Pages: 408-413 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) Institut für Experimentelle Hämatologie
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501400-005
Scopus ID 0024312257
PubMed ID 2788129
Erfassungsdatum 1989-12-31