Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Evaluation of 99mTc-dextran as a lymphoscintigraphic agent in rabbits.
Eur. J. Nucl. Med. Mol. Imaging 11, 80-84 (1985)
Dextran (clinical grade, average mol. wt. 82,200) was labelled with 99mTc and the labelling efficiency was checked by paper and thin-layer chromatography and electrophoresis. The amount of free 99mTcO4 -was always less than 1%. The radiopharmaceutical was injected ID into the web space in hind legs of ten rabbits (200-600 μCi/0.05 ml). Scintigrams were taken at 10-min intervals up to 3 h in three rabbits. The injection site and the hind legs were massaged after injection in the other seven rabbits and scintigrams were taken at 10-min intervals up to 2 h. Blood samples were obtained at 5, 15, 30, 90 and 120 min in both groups. In addition a 180-min sample, was also taken in the first group. At the end of the study the rabbits were killed and the popliteal lymph nodes and the organs were removed to be weighed, and counted. Our results indicated a high concentration of radioactivity in the popliteal lymph nodes and massage at the injection site increased the average uptake of the popliteal lymph node from 1.12%±0.77% to 4.28%±1.57% at 3 and 2 h, respectively (P<0.001). In scintigrams the lymph channels and the nodes were very well visualised. The blood radioactivity levels were too low to present a background problem. With massage 30% of the injected dose was removed from the injection site in 2 h. We have shown that 99mTc-dextran is a good radiopharmaceutical for the visualisation of the lymph system and deserves further experimental and clinical studies.
Impact Factor
Scopus SNIP
Scopus
Cited By
Cited By
Altmetric
0.000
0.000
27
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
99mtc-dextran ; Intradermal Injection ; Lymphoscintigraphy
Language
german
Publication Year
1985
HGF-reported in Year
0
ISSN (print) / ISBN
1619-7070
e-ISSN
1432-105X
Quellenangaben
Volume: 11,
Issue: 2-3,
Pages: 80-84
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Nuklearbiologie
PubMed ID
2412822
Scopus ID
0022270755
Erfassungsdatum
1985-08-03