PuSH - Publication Server of Helmholtz Zentrum München: Immunohistochemical identification of T-and B-lymphocytes delineated by the unlabelled antibody enzyme method. III. Topographical and quantitative distribution of T-and B-cells in human palatine tonsils.

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Hoffmann-Fezer, G. ; Loehrs, U. ; Rodt, H.V. ; Thierfelder, S.S.

Immunohistochemical identification of T-and B-lymphocytes delineated by the unlabelled antibody enzyme method. III. Topographical and quantitative distribution of T-and B-cells in human palatine tonsils.

Cell Tissue Res. 216, 361-375 (1981)

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T-lymphocytes and B-lymphocytes are identified in tissue sections of human tonsils by applying the unlabelled antibody enzyme method. The epithelium of the tonsils contains a majority of immunoglobulin-positive cells and fewer T-lymphocytes. In the subepithelial zones, areas composed of B-cells predominate, however, regions containing T-lymphocytes are also present. The latter are mainly arranged in the lamina propria around high-endothelial venules and often include plasma cells containing immunoglobulin. Follicles containing germinal centres display a complex structure which changes during development. The lymphocytic cap consists of densely packed lymphocytes, labelled heavily by anti-IgM and anti-IGD, and of individual T-lymphocytes. Germinal centres show a framework of immunoglobulin-positive dendritic reticular cells; they contain some heavily labelled lymphoid cells and several cells weakly labelled by anti-IgM and anti-IgA, as well as a small number of T-lymphocytes. Furthermore, the total areas of T- and B-lymphocytes measured by planimetry may differ considerably between different tonsils. Especially total areas of germinal centres vary to a great extent. The quantitative data on amounts of T- and B-cells achieved by planimetry are comparable to those reported in cellular suspensions of tonsils.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Immunohistochemistry; Human tonsil; T-lymphocytes; B-lymphocytes; Quantitative morphology

ISSN (print) / ISBN 0044-3794

e-ISSN 1432-0878

Journal Cell and Tissue Research

Quellenangaben Volume: 216, Issue: 2, Pages: 361-375

Publisher Springer

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institut für Hämatologie