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Müller, W.A. ; Luz, A. ; Murray, A.B. ; Linzner, U.

Induction of lymphoma and osteosarcoma in mice by single and protracted low α doses.

Health Phys. 59, 305-310 (1990)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Internal doses from the short-lived α-emitter 224Ra were given to 4-wk-old female NMRI mice. One group of about 300 animals received a single injection of 18.5 kBq 224Ra kg-1 body weight, corresponding to a mean skeletal α dose of 0.15 Gy. A second group of about 300 animals received the same total amount of 224Ra in the form of 72 fractions of 257 Bq kg-1 each, applied twice weekly during 36 wk. The fractionated group received the same final mean total skeletal dose of 0.15 Gy as the single injected group, but with a mean skeletal dose rate of 1 mGy d-1. A rather high incidence, 13.5% (40/296), of early malignant lymphomas was observed in the fractionated group during and shortly after the injection period, followed by a 7% incidence (21/296) of osteosarcomas during the second half of the animals' lifetime. The group with a single injection did not develop early lymphomas but did develop osteosarcomas later with an incidence of 5.8% (17/295). The occurrence of osteosarcomas was similar up to day 800 in the two experimental groups. Surprisingly, however, after this period no additional case of osteosarcoma was observed in the single-injected group, whereas one-third of all osteosarcomas occurred after day 800 in the protracted group. The additional later occurrence of osteosarcomas in the protracted group clearly indicates a longer lasting induction effect on osteosarcomas, or a promoting effect in older age, for this kind of treatment.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0017-9078
e-ISSN 1538-5159
Journal Health Physics
Quellenangaben Volume: 59, Issue: 3, Pages: 305-310 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)