PuSH - Publication Server of Helmholtz Zentrum München: Proliferative activity of bone marrow cells in acute lymphocytic leukemia: Variation of cell kinetics with clinical manifestation.

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Lau, B. ; Dörmér, P.G. ; Haas, R.J.* ; Janka, G.E.*

Proliferative activity of bone marrow cells in acute lymphocytic leukemia: Variation of cell kinetics with clinical manifestation.

Leuk. Res. 2, 241-245 (1978)

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Cell-kinetic investigations were carried out in a 15-year-old girl, initially presenting bicytopenia and changing gradually to cALL. At three instances during this transitional stage of the disease, the proliferation kinetics were studied in the cALL blast cell population as well as in erythroblasts and myelocytes. The percentage of blasts in the bone-marrow was 39, 42 and 70%, respectively. The DNA synthesis time in individual cells was measured by using the technique of quantitative 14C-autoradiography. Parallel with the increase in the number of blast cells a shortening of their time of DNA synthesis from 28.9 to 21.6 h was observed. Concomitantly with this development the kinetic parameters of erythroblasts and myelocytes normalized from initially extended values, and the anemia improved. A mutual inhibition between normal and malignant cell growth in bone marrow at the onset of overt leukemia is discussed as a possible interpretation of the course of the disease in this case.

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