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Open Access Green as soon as Postprint is submitted to ZB.
Intraluminal hexadecane enhances large intestinal excretion of tissue hexachlorobenzene in rats.
Toxicol. Lett. 16, 253-257 (1983)
In young adult female rats with a cecal stoma, administration of hexadecane into the stomach (750 or 500 mg) and into the ligated colon (250 mg) enhanced 2- to 3-fold the intestinal excretion of [14C]hexachlorobenzene. Apparent sites of increased transferral from the blood into luminal contents were (caudal) ileum, cecum and colon. Presence of nonabsorbed hexadecane in luminal contents seems to be a prerequisite for the effects. Results support previous reports that enhancement of intestinal excretion of lipophilic chemicals by liquid paraffins takes place in the large intestine.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0378-4274
e-ISSN
1879-3169
Journal
Toxicology Letters
Quellenangaben
Volume: 16,
Issue: 3-4,
Pages: 253-257
Publisher
Elsevier
Publishing Place
Amsterdam
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie