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Wiebel, F.J. ; Wolff, T. ; Lambiotte, M.

Presence of cytochrome P-450- and cytochrome P-448-dependent monooxygenase functions in hepatoma cell lines.

Biochem. Biophys. Res. Commun. 94, 466-472 (1980)

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Open Access Green as soon as Postprint is submitted to ZB.

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Cell lines derived from Reuber H-4-II-E hepatoma cells and their hybrids that differ in the expression of liver-specific functions are shown to contain different forms of monooxygenases. According to the specificity toward the substrates benzo(a)pyrene, aldrin and chenodeoxycholic acid, the kinetics of the epoxidation of aldrin, the response to inducers, such as benz(a)anthracene and dexamethasone, and the in vitro modifier 7,8-benzoflavone, the monooxygenases predominating in differentiated cell lines belong to the cytochrome P-450-dependent enzyme(s), those in the less differentiated lines belong to the cytochrome P-448-dependent form(s).

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 0006-291X

e-ISSN 1090-2104

Journal Biochemical and Biophysical Research Communications

Quellenangaben Volume: 94, Issue: 2, Pages: 466-472

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institut für Toxikologie und Biochemie