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Open Access Green as soon as Postprint is submitted to ZB.
Presence of cytochrome P-450- and cytochrome P-448-dependent monooxygenase functions in hepatoma cell lines.
Biochem. Biophys. Res. Commun. 94, 466-472 (1980)
Cell lines derived from Reuber H-4-II-E hepatoma cells and their hybrids that differ in the expression of liver-specific functions are shown to contain different forms of monooxygenases. According to the specificity toward the substrates benzo(a)pyrene, aldrin and chenodeoxycholic acid, the kinetics of the epoxidation of aldrin, the response to inducers, such as benz(a)anthracene and dexamethasone, and the in vitro modifier 7,8-benzoflavone, the monooxygenases predominating in differentiated cell lines belong to the cytochrome P-450-dependent enzyme(s), those in the less differentiated lines belong to the cytochrome P-448-dependent form(s).
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0006-291X
e-ISSN
1090-2104
Quellenangaben
Volume: 94,
Issue: 2,
Pages: 466-472
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie und Biochemie