PuSH - Publication Server of Helmholtz Zentrum München: Evidence for the involvement of cytochrome P-450-dependent monooxygenase(S) in the formation of genotoxic metabolites from N-hydroxyurea.

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Andrae, U.

Evidence for the involvement of cytochrome P-450-dependent monooxygenase(S) in the formation of genotoxic metabolites from N-hydroxyurea.

Biochem. Biophys. Res. Commun. 118, 409-415 (1984)

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Hydroxyurea induces DNA repair replication in the cytochrome P-450-containing C2Rev7 rat hepatoma cell line. Repair is severalfold increased by pretreatment of the cells with dexamethasone, which induces cytochrome P-450-dependent monooxygenase activities in these cells. In the dedifferentiated hepatoma line H5, which strongly expresses cytochrome P-448 but no cytochrome P-450-dependent enzyme activities, hydroxyurea is not genotoxic. The results support the notion that the formation of genotoxic metabolites from hydroxyurea is mediated by a cytochrome P-450-dependent enzyme.

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