PuSH - Publication Server of Helmholtz Zentrum München: Verzögerte Implantation und frühembryonale Keimschaden bei der Maus nach Applikation des PCB: 2,2'-Dichlorbiphenyl.

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Toeroek, P.

Verzögerte Implantation und frühembryonale Keimschaden bei der Maus nach Applikation des PCB: 2,2'-Dichlorbiphenyl.

Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl.

Arch. Toxicol. 40, 249-254 (1978)

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Pregnant mice administered per os during the days 1-3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kg/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 mg/kg/day led to a substantial retardation of the prenatal development. Based on the investigations during the early development it is concluded, that retardation of the fetus is caused by a delayed implantation. It is assumed, that increased resorption is due to kyematopathies detected during the periimplantation period.

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