Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text
DOI
 |
Licenced for HMGU |
Open Access Green as soon as Postprint is submitted to ZB.
Multiple regions of alpha-synuclein are associated with parkinson's disease.
Ann. Neurol. 57, 535-541 (2005)
Publ. Version/Full Text
DOI
α-Synuclein is considered to play an important role in the pathogenesis of both the rare familial and the common sporadic forms of Parkinson's disease. Previous reports primarily have tested the association of α-synuclein promoter polymorphisms with idiopathic Parkinson's disease, but results are controversial. We first characterized the linkage disequilibrium structure of the α-synuclein gene region with a dense set of 56 genetic markers and subsequently performed two independent case–control association analyses using tagging markers. We could distinguish two large linkage disequilibrium blocks spanning the α-synuclein gene. Several markers within the 3′-block around exons 5 and 6 showed strong association with Parkinson's disease (p = 0.00009). Effects of the associated variants might be mediated by regulatory elements in this highly conserved region or by a frequency shift in a previously described splice variant lacking exon 5. A direct association with promoter polymorphisms could not be replicated in our sample set. A second set of markers in the 5′-block of the gene were also significantly associated with Parkinson's disease, when young patients and female subjects were analyzed separately. These findings indicate locus heterogeneity for the pathogenesis of Parkinson's disease in different genetic or physiological environments, related to sex and age.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
8.097
0.000
155
183
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2005
HGF-reported in Year
2005
ISSN (print) / ISBN
0364-5134
e-ISSN
1531-8249
Journal
Annals of Neurology
Quellenangaben
Volume: 57,
Issue: 4,
Pages: 535-541
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Human Genetics (IHG)
POF-Topic(s)
30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-503900-003
G-500700-001
G-500700-001
Erfassungsdatum
2005-08-10