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Open Access Green as soon as Postprint is submitted to ZB.
Dose-dependent emergence of preneoplastic foci in rat livers after exposure to 2-nitropropane.
Arch. Toxicol. 64, 329-331 (1990)
Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. Thirteen weeks after starting the experiments the logarithms of the numbers of preneoplastic liver foci deficient in adenosine-5′-triphosphatase were found to be linearly related to the exposure concentrations of 2-nitropropane. Male rats exhibited an approximately four times lower foci incidence than females.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
2-nitropropane ; Inhalation ; Preneoplastic Liver Foci ; Rats
ISSN (print) / ISBN
0340-5761
e-ISSN
1432-0738
Journal
Archives of Toxicology
Quellenangaben
Volume: 64,
Issue: 4,
Pages: 329-331
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie