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Denk, B. ; Filser, J.G. ; Deml, E. ; Kessler, W. ; Shen, J. ; Oesterle, D.

Dose-dependent emergence of preneoplastic foci in rat livers after exposure to 2-nitropropane.

Arch. Toxicol. 64, 329-331 (1990)

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Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. Thirteen weeks after starting the experiments the logarithms of the numbers of preneoplastic liver foci deficient in adenosine-5′-triphosphatase were found to be linearly related to the exposure concentrations of 2-nitropropane. Male rats exhibited an approximately four times lower foci incidence than females.

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