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Strauß, P.G. ; Schmid, J. ; Pedersen, L.M. ; Erfle, V.F.

Amplification of endogenous proviral MuLV sequences in radiation-induced osteosarcomas.

Int. J. Cancer 41, 616-621 (1988)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The endogenous ecotropic provirus of BALB/c mice was found to be amplified in 17 out of 29 radiation-induced osteosarcomas. In contrast, 19 clonal cell lines established from bone-marrow cells of a tumor-bearing mouse, which were used as controls, did not reveal newly acquired ecotropic proviruses. Ecotropic viral RNA was expressed in tumors that showed reintegrated proviruses. DNA probes from 2 tumors, derived from cellular sequences flanking the newly integrated proviruses, did not detect DNA rearrangements in any of the other tumors. The possible role of activated endogenous retroviruses in the development of radiation-induced osteosarcomas is discussed.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Journal International Journal of Cancer
Quellenangaben Volume: 41, Issue: 4, Pages: 616-621 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)