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Open Access Green as soon as Postprint is submitted to ZB.
Pharmacokinetics and hepatotoxicity of 2-nitropropane in rats.
Arch. Toxicol. 63, 330-332 (1989)
The solvent 2-nitropropane (2-NP) has been reported to produce liver necrosis and hepatocarcinoma in rats, males being much more sensitive than females (Griffin et al 1980). Since this may be caused by sex specific pharmacokinetics of 2-NP inhalation kinetics in male and in female Sprague-Dawley rats were investigated. Furthermore, as specific indicators of parenchymal hepatic injury the response of glutamic oxalacetic transaminase (GOT) and of glutamic pyruvic transaminase (GPT) was studied in serum after application of 2-NP to the animals.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0340-5761
e-ISSN
1432-0738
Conference Title
Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances
Journal
Archives of Toxicology
Quellenangaben
Volume: 63,
Pages: 330-332
Publisher
Springer
Reviewing status
Peer reviewed