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Pharmacokinetics and hepatotoxicity of 2-nitropropane in rats.

Arch. Toxicol. 63, 330-332 (1989)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The solvent 2-nitropropane (2-NP) has been reported to produce liver necrosis and hepatocarcinoma in rats, males being much more sensitive than females (Griffin et al 1980). Since this may be caused by sex specific pharmacokinetics of 2-NP inhalation kinetics in male and in female Sprague-Dawley rats were investigated. Furthermore, as specific indicators of parenchymal hepatic injury the response of glutamic oxalacetic transaminase (GOT) and of glutamic pyruvic transaminase (GPT) was studied in serum after application of 2-NP to the animals.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1989
HGF-reported in Year 0
ISSN (print) / ISBN 0340-5761
e-ISSN 1432-0738
Conference Title Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances
Quellenangaben Volume: 63, Issue: , Pages: 330-332 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Scopus ID 0024388413
PubMed ID 2774957
Erfassungsdatum 1989-11-11