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Open Access Green as soon as Postprint is submitted to ZB.
Amplification and rearrangement of c-myc in radiation-induced murine osteosarcomas.
Cancer Res. 50, 4146-4153 (1990)
Fifty-one radiation-induced murine osteosarcomas were investigated for alterations in c-myc gene structure and c-myc expression. Amplification of c-myc was found in 30% of BALB/c tumors and 13% of NMRI tumors. A region of common proviral integration, Mlvi-1, localized on the same region on chromosome 15, was amplified concomitantly. Multiple copies of both loci were localized on double minutes. Three of the tumors with c-myc amplification also showed rearrangements of the c-myc gene region. One of these rearrangements included the 5′ and 3′-flanking sequences and the noncoding part of the third exon. Repetitive sequences were found in the 5′ region of the c-myc gene, and the 3′ flanking region was substituted by sequences normally present in a more distant part of chromosome 15. Increased levels of c-myc transcripts of apparently normal size were found in tumors carrying amplified c-myc sequences. Abnormally high expression of c-myc in some tumors was correlated with an early stage of osteogenic differentiation, suggesting the involvement of the c-myc gene in the control of the osteogenic differentiation of transformed cells.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0008-5472
e-ISSN
1538-7445
Journal
Cancer Research
Quellenangaben
Volume: 50,
Issue: 13,
Pages: 4146-4153
Publisher
American Association for Cancer Research (AACR)
Publishing Place
Philadelphia, Pa.
Reviewing status
Peer reviewed
Institute(s)
Abteilung für molekulare Zellpathologie