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Open Access Green as soon as Postprint is submitted to ZB.
Quantitative and comparative study of haematoporphyrin-derived photosensitizers on a murine tumour model.
Lasers Med. Sci. 5, 309-316 (1990)
Eight commercially available HPD-photosensitizers intended for photodynamic therapy were tested in a murine tumour model with regard to their therapeutic efficacy. The regrowth delay of the fibrosarcoma SSK-2 on the mouse C3H, Neuherberg-line, was determined 3, 24, 48 and 72 h after injection of the drugs (dose: 9 mg kg-1 body weight). The corresponding pharmacodynamics, as measured by regrowth delay, were approximated by an exponential function and the characterizing coefficients derived. These coefficients served to quantify the photodynamic properties of the drugs. The pharmacodynamics of five substances were compared with those obtained fluorometrically. The latter showed shorter decay constants than the therapy-correlated substances which indicates different metabolic behaviour of the therapeutic and diagnostically useful fluorescent components of haematoporphyrin-derived photosensitizers.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diagnosis ; Fluorescence ; Haematoporphyrin Derivative ; Hpd ; Laser ; Murine Tumour ; Pdt ; Pharmacodynamic ; Pharmacokinetic ; Photodynamic Therapy ; Regrowth Delay
ISSN (print) / ISBN
0268-8921
e-ISSN
1435-604x
Journal
Lasers in Medical Science
Quellenangaben
Volume: 5,
Issue: 3,
Pages: 309-316
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie