PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Born, R. ; Eichholtz-Wirth, H.

Effect of different physiological conditions of the action of adriamycin on Chinese hamster cells in vitro.

Br. J. Cancer 44, 241-246 (1981)
Publ. Version/Full Text DOI
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Chronically hypoxic cells were 5 times more resistant to Adriamycin (ADR) than exponentially growing oxic cells. On reoxygenation, resistance decreased slowly to reach the ADR sensitivity of oxic cells after 24 h. With increasing pH, ADR efficiency increased more in oxic than in chronically hypoxic cells. With increasing cell density, ADR efficiency decreased linearly. The differences in ADR efficiency under the various conditions were accompanied by differences in intracellular ADR uptake. Chronically hypoxic cells incorporated 1.6 times less than oxic cells; the incorporation rate at pH 6.5 was half that at pH 7.4; and at a cell density of 5x105/bottle the intracellular uptake was 6 times that at 5x106/bottle. The observed differences in uptake of ADR were not, however, sufficient to explain the differences in cytotoxicity.
Impact Factor
Scopus SNIP
Altmetric
0.000
0.000
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1981
HGF-reported in Year 0
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Journal British Journal of Cancer BJC
Quellenangaben Volume: 44, Issue: 2, Pages: 241-246 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Abteilung für Strahlenbiologie und Biophysik
Scopus ID 0019465470
Erfassungsdatum 1981-12-31
[➜Report correction]