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Open Access Green as soon as Postprint is submitted to ZB.
Effect of different physiological conditions of the action of adriamycin on Chinese hamster cells in vitro.
Br. J. Cancer 44, 241-246 (1981)
Chronically hypoxic cells were 5 times more resistant to Adriamycin (ADR) than exponentially growing oxic cells. On reoxygenation, resistance decreased slowly to reach the ADR sensitivity of oxic cells after 24 h. With increasing pH, ADR efficiency increased more in oxic than in chronically hypoxic cells. With increasing cell density, ADR efficiency decreased linearly. The differences in ADR efficiency under the various conditions were accompanied by differences in intracellular ADR uptake. Chronically hypoxic cells incorporated 1.6 times less than oxic cells; the incorporation rate at pH 6.5 was half that at pH 7.4; and at a cell density of 5x105/bottle the intracellular uptake was 6 times that at 5x106/bottle. The observed differences in uptake of ADR were not, however, sufficient to explain the differences in cytotoxicity.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0007-0920
e-ISSN
1532-1827
Journal
British Journal of Cancer BJC
Quellenangaben
Volume: 44,
Issue: 2,
Pages: 241-246
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik