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Open Access Green as soon as Postprint is submitted to ZB.
The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas.
Diagn. Mol. Pathol. 16, 222-228 (2007)
Endometrial cancer is the most common gynecologic cancer in the developed world. The cell-adhesion protein E-cadherin acts as a tumor-suppressor protein and is down-regulated by the transcription factor Snail, whose expression was shown to be associated with estrogen receptor signaling. This study aimed to investigate the expression of E-cadherin, Snail, and estrogen-receptor alpha in 87 primary tumors and 26 metastases of endometroid endometrial carcinomas. Reduced E-cadherin immunoreactivity was seen in 44.8% of the primary tumors and 65.4% of the metastases with a statistical correlation to higher tumor grade (P=0.003) only in metastatic lesions. About 28.7% of primary tumor specimens showed a positive Snail immunoreactivity that was correlated with reduced estrogen-receptor alpha expression (P=0.047). Positive Snail immunoreactivity was also seen in 53.8% of the metastases where it was correlated with higher tumor grade (P=0.003) and abnormal E-cadherin expression (P=0.003). Interestingly, a Snail expressing endometrial carcinoma-cell line showed a higher migration potential than a variant of this cell line with low levels of Snail. Taken together, our data are in line with a proposed role for Snail in endometrial tumor progression.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
E-cadherin; Snail; immunohistochemistry; endometrial carcinoma
ISSN (print) / ISBN
1052-9551
e-ISSN
1533-4066
Journal
Diagnostic Molecular Pathology
Quellenangaben
Volume: 16,
Issue: 4,
Pages: 222-228
Publisher
Lippincott Williams & Wilkins
Non-patent literature
Publications
Reviewing status
Peer reviewed