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Open Access Green as soon as Postprint is submitted to ZB.
Absorption, transport and organotropism of dichlorobiphenyl (DCB), Dieldrin, and hexachlorobenzene (HCB) in rats.
Environ. Res. 10, 384-389 (1975)
Sprague-Dawley rats were given a single dose of 150 μg of 14C-labeled DCB, Dieldrin, or HCB by stomach tube. At 1, 3, 5, 12, and 48 hour following dosing, one male and one female were killed. Samples of each organ or tissue were combusted and the 14CO2 content determined and the results averaged and recorded. DCB was rapidly absorbed from the gastrointestinal tract and transported to the liver mainly via the portal venous system, metabolized rapidly by the liver and excreted without significant storage. Dieldrin was similarly absorbed and transported to the liver; however, only a portion was metabolized and excreted, with redistribution and subsequent storage of most Dieldrin in the adipose tissue. HCB was more slowly absorbed with minor involvement of the portal venous system, and major absorption by the lymphatic system with subsequent deposition in the fat.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0013-9351
e-ISSN
1096-0953
Journal
Environmental Research
Quellenangaben
Volume: 10,
Issue: 3,
Pages: 384-389
Publisher
Elsevier
Publishing Place
San Diego, Calif.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)