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Brack-Werner, R. ; Leib-Mösch, C. ; Werner, T. ; Erfle, V.F. ; Hehlmann, R.

Human endogenous retrovirus-like sequences.

Haematology and Blood Transfusion 32, 464-477 (1989)
DOI PMC
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to also persist in the germ line of animal cells. In this case, they have become an endogenous constituent of their host cell’s genome and are passed on as stable Mendelian genes from one generation to the next.        
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Publication type Article: Journal article
Document type Scientific Article
Journal Haematology and Blood Transfusion
Quellenangaben Volume: 32, Issue: , Pages: 464-477 Article Number: , Supplement: ,
Publisher Springer
Institute(s) Abteilung für molekulare Zellpathologie
Institut für Säugetiergenetik