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Open Access Green as soon as Postprint is submitted to ZB.
Evidence for different mechanisms of action of the three pyrethroids, deltamethrin, cypermethrin, and fenvalerate, on the excitation threshold of myelinated nerve.
Pestic. Biochem. Physiol. 28, 67-74 (1987)
The effects of three α-cyano pyrethroids (deltamethrin, fenvalerate, and cypermethrin) on the electrophysiological function of single myelinated nerve fibers from Rana esculenta were investigated. The time course of pyrethroid-induced changes on the threshold interval, Vs − Vm (Vs: threshold voltage; Vm: membrane potential), as well as stationary membrane parameters determining this interval was measured on the same nerve preparation (membrane potential Vm, stationary transition voltage VTr, stationary sodium conductance). The results suggest that the mechanisms of changing the threshold interval are different for the three pyrethroids. Deltamethrin and cypermethrin increase this interval until inexcitability, deltamethrin by increasing the stationary sodium conductance and cypermethrin by blocking the sodium conductance. Fenvalerate, however, insignificantly affects the threshold interval because both Vm and Vs are shifted parallel by about the same amount in the same direction (depolarization). These qualitatively different effects of chemically related substances differentiate the pyrethroids from other classes of substances which are effective on the nerve function and suggests that the molecular mechanisms underlying the pyrethroid effects might have a unique quality.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0048-3575
e-ISSN
0048-3575
Quellenangaben
Volume: 28,
Issue: 1,
Pages: 67-74
Publisher
Elsevier
Institute(s)
Abteilung für Physiologie