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Sandermann, H.J.

Mutagenic activation of xenobiotics by plant enzymes.

Mutat. Res. -Fund. Mol. Mech. Mutag. 197, 183-194 (1988)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Genetic evidence has indicated that plants can activate certain xenobiotics to mutagens, but biochemical evidence is as yet scarce. Nevertheless, plant microsomal enzymes and peroxidases have been shown to form reactive intermediates, the best studied examples being 2-aminofluorene, benzo[a]pyrene and pentachlorophenol. The latter two xenobiotics are converted to quinoid derivatives which are, in principle, able to redox cycle and generate active oxygen species. In analogy to results obtained in mammalian systems, covalent binding of reactive intermediates to DNA as well as fragmentation of DNA, are proposed as major mechanisms of action of mutagenic plant metabolites.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 2-aminofluorene ; Benzo[a]pyrene ; Microsomal Enzymes ; Pentachlorophenol ; Peroxidases ; Plant Enzymes ; Xenobiotics
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
Quellenangaben Volume: 197, Issue: 2, Pages: 183-194 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Biochemical Plant Pathology (BIOP)