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Pyruvate and related α-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity.

Toxicol. Lett. 28, 93-98 (1985)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Pyruvate efficiently protected V79 Chinese hamster cells against the lethal effects of hydrogen peroxide. Protection was also provided by other α-ketoacids, such as α-ketobutyrate, α-ketoglutarate and α-ketoadipate, although higher concentrations were required. The corresponding β-ketoacids had no effect. The results indicate that pyruvate and other α-ketoacids possess antioxidant activity in vitro and, probably, in vivo.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Quellenangaben Volume: 28, Issue: 2-3, Pages: 93-98 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institut für Toxikologie und Biochemie