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Open Access Green as soon as Postprint is submitted to ZB.
Pyruvate and related α-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity.
Toxicol. Lett. 28, 93-98 (1985)
Pyruvate efficiently protected V79 Chinese hamster cells against the lethal effects of hydrogen peroxide. Protection was also provided by other α-ketoacids, such as α-ketobutyrate, α-ketoglutarate and α-ketoadipate, although higher concentrations were required. The corresponding β-ketoacids had no effect. The results indicate that pyruvate and other α-ketoacids possess antioxidant activity in vitro and, probably, in vivo.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0378-4274
e-ISSN
1879-3169
Journal
Toxicology Letters
Quellenangaben
Volume: 28,
Issue: 2-3,
Pages: 93-98
Publisher
Elsevier
Publishing Place
Amsterdam
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie und Biochemie