PuSH - Publication Server of Helmholtz Zentrum München: Promoting action of radiation in the atomic bomb survivor carcinogenesis data?

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Heidenreich, W.F. ; Cullings, H.M.* ; Funamoto, S.* ; Paretzke, H.G.

Promoting action of radiation in the atomic bomb survivor carcinogenesis data?

Radiat. Res. 168, 750-756 (2007)

Publ. Version/Full Text

DOI

PMC

	Licenced for HMGU

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Promoting Action of Radiation in the Atomic Bomb Survivor Carcinogenesis Data? Radiat. Res. 168, 750- 756 (2007).The age-time patterns of risk in the atomic bomb survivor data on incidence of solid cancers suggest an action of low-LET radiation not only on the initiating event but also on promotion in a biologically motivated model that allows for both actions. The favored model indicates a decrease of radiation risks with age at exposure due to the initiating effect and with time since exposure due to the promoting effect. These result in a relative risk that depends mostly on attained age for ages at exposure above 20 years. According to the model, a dose of 100 mGy is inducing about the same number of initiating events that occur spontaneously in 1 year. Assuming that several mutations are needed to obtain intermediate cells with growth advantage does not improve the quality of fit. The estimated promoting effect could be explained if the number of intermediate cells increases by 80% at 1 Gy, e.g. due to stimulated cell repopulation.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

2.602

0.000