The applicability of bone-scanning procedures in bone healing was studied in animals. Standardized segmental tibial defects in dogs were stabilized by established internal osteosynthesis and were replaced using fresh autologous cancellous bone grafts or collagen sponges, both in combination with homologous fibrin glue. Consecutive postoperative controls of bone remodeling by99mTechnetiummethylendiphosphonate skeletal uptake, and comparing gamma camera with X-ray pictures revealed the value of this bone-seeking radionuclide for determination of the osteogenetic ability of traumatized bone specially in the early phase.