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Open Access Green as soon as Postprint is submitted to ZB.
Calcium in lipid peroxidation: Does calcium interact with superoxide?
Arch. Biochem. Biophys. 278, 269-272 (1990)
Using a pulse radiolysis approach to generate and observe superoxide anions (superoxide) in the absence and presence of calcium, we have attempted to verify the recent hypothesis of Babizahyev (Arch. Biochem. Biophys. 266, 446-451, 1988) of a Ca2+-superoxide interaction during lipid peroxidation. We could not observe rapid scavenging of superoxide or complex formation with Ca2+ to account for an inhibitory effect of this cation on lipid peroxidation. Neither could we agree that the stimulatory effect is due to liberation of catalytic ferrous iron from weak complexes by Ca2+. Drawing on reports in the literature, we propose an alternate explanation for the apparent stimulation of lipid peroxidation by low Ca2+ concentrations. In our view, this is not a direct effect, but reflects independently initiated processes of lipid peroxidation and Ca2+ translocation, which interact subsequently in a synergistic manner. The reported inhibition at high Ca2+ concentrations is considered an artifact as it was observed at levels far in excess of those relevant to animal systems (but not necessarily in some plant compartments).
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0003-9861
e-ISSN
1096-0384
Quellenangaben
Volume: 278,
Issue: 1,
Pages: 269-272
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik