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Favor, J. ; Neuhüser-Klaus, A. ; Ehling, U.H.

The frequency of dominant cataract and recessive specific-locus mutations and mutation mosaics in F1 mice derived from post-spermatogonial treatment with ethylnitrosourea.

Mutat. Res. -Fund. Mol. Mech. Mutag. 229, 105-114 (1990)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The frequency of dominant cataract and recessive specific-locus mutations and mutation mosaics was determined in F1 mice derived from post-spermatogonial germ-cell stage treatment with 2 × 80, 160 or 250 mg/kg ethylnitrosourea. A total of 5 dominant cataract mutations, 3 dominant cataract mutation mosaics, 1 specific-locus mutation and 9 specific-locus mutation mosaics were recovered in 15,542 screened F1 offspring. Results indicate that ethylnitrosourea treatment increases the mutation rate of dominant cataract and recessive specific-locus alleles in post-spermatogonial germ-cell stages of the mouse and that the mutations occur mainly as mosaics. Genetic confirmation of newly induced mutations occurring as mosaics is more problemtical for induced recessive alleles than for induced dominant alleles and should be considered when evaluating such mutagenicity results.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Dominant Cataract Mutations ; Ethylnitrosourea ; Mouse ; Mutation Mosaics ; Post-spermatogonial Germ-cell Stage Treatment ; Specific-locus Mutations
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
Quellenangaben Volume: 229, Issue: 2, Pages: 105-114 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institut für Säugetiergenetik