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Open Access Green as soon as Postprint is submitted to ZB.
Oxidative stress and inherited cataracts in mice.
Ophthalmic Res. 21, 414-419 (1989)
To determine whether an unbalanced redox state might accompany the development of particular inherited mouse cataracts, the lenticular content of oxidized glutathione (GSSG) and the activity of superoxide dismutase (SOD) were chosen as markers. For wild-type lenses, an enhanced GSSG content could be observed in females as compared to males. Such a sex effect could not be detected for the SOD activity. In the mutants, GSSG content in cataractous lenses was found to be enhanced in 2 of 7 cases; the increases in other mutants were not significant. Changes of the SOD activity were even less consistent and only a random correlation of GSSG content and SOD activity with cataractogenesis could be deduced.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cataract, Mouse ; Dominant Mutation ; Glutathione ; Statistical Analysis ; Superoxide Dismutase
ISSN (print) / ISBN
0030-3747
e-ISSN
1423-0259
Journal
Ophthalmic Research
Quellenangaben
Volume: 21,
Issue: 6,
Pages: 414-419
Publisher
Karger
Non-patent literature
Publications
Reviewing status
Peer reviewed