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Baldauf, W. ; Wurzinger, L.J. ; Kinder, J.

The role of stagnation point flow in the formation of platelet thrombi on glass surfaces in tubes with various geometry.

Pathol. Res. Pract. 163, 9-33 (1978)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Glass models of small rectangularly branched and 360° curved arteries have been perfused with diluted bovine platelet rich plasma activated with ADP. Whereas straight tube flow did not lead to platelet deposits, branched tube flow caused thrombi at two sites. First site was the region of the distal rim of the orifice of the side branch, second site was the wall of the main tube opposite and downstream the side branch origin. Curved tube flow produced deposits on the wall with the smaller radius and on the wall with the greater radius of curvature. The formation of deposits at the specific sites required definite flow conditions. Thrombi at sites corresponding to the predilection sites of atherosclerosis in small arteries, i.e. the wall opposite the side branch and the wall with the smaller radius of curvature, occured where flow separated from the wall, reattaches forming a stagnation point flow. The influence of stagnation point flows on thrombus formation on glass walls was studied quantitatively for a rotationally symmetric stagnation point flow. The experiments revealed that, activated bovine platelets adhere only where they are transported by flows to the wall exhibiting velocity components directed perpendicularly towards the wall; polycellular stripe like thrombi form only when the velocity components of platelets parallel to the wall overcomes a critical value; the mass of deposited polycellular thrombi increases with the velocity component parallel to the wall. For all deposits a critical parallel velocity component exists which dislodges thrombi.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0344-0338
e-ISSN 1618-0631
Journal Pathology, Research and Practice
Quellenangaben Volume: 163, Issue: 1, Pages: 9-33 Article Number: , Supplement: ,
Publisher Urban & Fischer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Departments & Institutes