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Open Access Green as soon as Postprint is submitted to ZB.
Current aspects on the radiation induced base damage in DNA.
Radiat. Environ. Biophys. 25, 261-271 (1986)
In this review, some current aspects of our knowledge about base damage in DNA induced by ionizing radiation will be summarized. The understanding of DNA base damage requires the analysis of radicals formed in irradiated single DNA moieties as well as in whole DNA. Chemical studies about can be used for the molecular alterations of bases and biochemical methods for DNA-sequencing. In addition enzymes recognizing DNA damage and immunological methods with specific antibodies can be employed. However special emphasis should be given to the analysis of DNA base damage in irradiated cells and it will be shown, that a distinct gap in knowledge exists in this field in contrast to the radiation chemistry in aqueous solutions of DNA.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Quellenangaben
Volume: 25,
Issue: 4,
Pages: 261-271
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)