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Open Access Green as soon as Postprint is submitted to ZB.
Cytogenetic and molecular analysis of a "masked" Philadelphia chromosome in chronic and blastic phases of chronic myeloid leukemia.
Cancer Genet. Cytogenet. 47, 219-225 (1990)
A "masked" Philadelphia chromosome (Ph), t(1;22;9)(p32;q11;q34), was found in the bone marrow and peripheral blood cells of a patient with chronic myeloid leukemia (CML) during the chronic and blastic phases of the disease. As an additional change, a reciprocal translocation t(12;13)(p13;q14) was observed in the blastic phase. Southern blot analysis showed a rearrangement of the breakpoint cluster region (bcr). Northern blot analysis with a c-abl probe showed an abnormal 8.5 kb c-abl RNA transcript in addition to the normal 6- and 7-kilobase (kb) c-abl species. Thus, the results demonstrate the presence of a c-abl/bcr rearrangement in the masked Ph corresponding to that observed in the standard Ph translocation t(9;22)(q34;q11) of CML.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0165-4608
e-ISSN
1873-4456
Journal
Cancer Genetics and Cytogenetics
Quellenangaben
Volume: 47,
Issue: 2,
Pages: 219-225
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik