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Open Access Green as soon as Postprint is submitted to ZB.
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?.
J. Cancer Res. Clin. Oncol. 97, 109-117 (1980)
Long-term animal experiments with prenatally X-irradiated offspring have so far not unequivocally settled the question of elevated tumor susceptibility. We have pursued this problem further in a modified 2-stage carcinogenesis-Berenblum/Mottram experiment. Prenatal X-irradiation of mice has thus been regarded as a possible initiator stimulus, with a postnatal promotion stimulus being given by applying the phorbol ester TPA to the offsprings' skin. This treatment has, however, not produced a higher tumor yield, neither of the skin nor of the internal organs, than that produced by X-irradiation in utero alone. This failure seems partly due to the dysplastic nature of the epidermis of prenatally X-irradiated mice, which also fails to respond to TPA application by way of hyperplasia or by an increased inflammation tendency and ulcer formation. We suggest that a decrease in prostaglandin synthesis after prenatal X-irradiation is an important factor for the unchanged tumor susceptibility, especially of the skin.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Carcinogenesis ; Diaplacental ; Phorbol Ester Promotion ; X-ray Initiation
ISSN (print) / ISBN
0171-5216
e-ISSN
1432-1335
Quellenangaben
Volume: 97,
Issue: 2,
Pages: 109-117
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Nuklearbiologie