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Open Access Green as soon as Postprint is submitted to ZB.
Chemical damage in gamma-irradiated human erythrocyte membranes.
Int. J. Radiat. Biol. 38, 159-166 (1980)
In air saturated suspensions of erythrocyte ghost membranes γirradiation causes formation of lipid peroxides, measured as malonaldehyde, and a loss of membrane protein sulphydryl groups. Addition of N-(p-amino-benzoyl)-1-glutamate prevented peroxidation up to doses of 2 × 103 Gy, due to scavenging of hydroxyl radicals. Another hydroxyl scavenger sodium formate, also prevented peroxidation at low doses, but lost its protective effect at higher doses probably because of secondary reactions of the resulting superoxide radical anion. Two sulphur containing radioprotectants also were able to reduce the extent of lipid peroxidation. The enzymes catalase and superoxide dismutase were added to the irradiated suspensions in order to determine the contribution from hydrogen peroxide and superoxide to peroxidation. The extents of peroxidation are compared with structural modification of the membrane under the same conditions of irradiation.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Quellenangaben
Volume: 38,
Issue: 2,
Pages: 159-166
Publisher
Informa Healthcare
Reviewing status
Peer reviewed
Institute(s)
Abteilung Biophysikalische Strahlenforschung