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Open Access Green as soon as Postprint is submitted to ZB.
Bioconcentration potential of organic environmental chemicals in humans.
Regul. Toxiol. Pharmacol. 6, 313-347 (1986)
A list of environmental chemicals detectable in adipose tissue and/or milk of non-occupationally exposed humans is presented. Besides their physicochemical properties (n-octanol/water partition coefficient and water solubility), their acceptable daily intake (ADI) values, production figures, fate in the environment, concentrations in human adipose tissue, and data from total diet studies from market basket investigations are given. Average bioconcentration factors (BCF) of polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), DDT, hexachlorobenzene (HCB), dieldrin, hexachlorocyclohexane isomers (α-HCH, β-HCH, γ-HCH, δ-HCH), pentachlorophenol (PCP), and 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in human adipose tissue are calculated. The bioconcentration factors (wet wt basis) of these compounds are between 3 and 47 times higher in humans than in rats. The environmental chemicals are divided into three groups in respect to their bioconcentration factors in human adipose tissue: group I, high BCF (>100); group II, medium BCF (10-100); and group III, low BCF (<10). The bioconcentration factors are useful for hazard assessment of chemicals to humans.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0273-2300
e-ISSN
1096-0295
Quellenangaben
Volume: 6,
Issue: 4,
Pages: 313-347
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)