PuSH - Publication Server of Helmholtz Zentrum München: Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.

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Kerler, F. ; Ziegler, I. ; Schwarzkopf, B. ; Bacher, A.

Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.

FEBS Lett. 250, 622-624 (1989)

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Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase. GTP-cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities contunue to increase during the 72 h period measured. The specific activities of 6-pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP-cyclohydrolase and sepiapterin reductase.

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