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Open Access Green as soon as Postprint is submitted to ZB.
Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.
FEBS Lett. 250, 622-624 (1989)
Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase. GTP-cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities contunue to increase during the 72 h period measured. The specific activities of 6-pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP-cyclohydrolase and sepiapterin reductase.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Quellenangaben
Volume: 250,
Issue: 2,
Pages: 622-624
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institut für Experimentelle Hämatologie