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Cuomo, C.A.* ; Güldener, U. ; Xu, J.R.* ; Trail, F.* ; Turgeon, B.G.* ; Di, Pietro, A.* ; Walton, J.D.* ; Ma, L.J.* ; Baker, S.E.* ; Rep, M.* ; Adam, G.* ; Antoniw, J.* ; Baldwin, T.* ; Calvo, S.* ; Chang, Y.L.* ; Decaprio, D.* ; Gale, L.R.* ; Gnerre, S.* ; Goswami, R.S.* ; Hammond-Kosack, K.* ; Harris, L.J.* ; Hilburn, K.* ; Kennell, JC.* ; Kroken, S.* ; Magnuson, J.K.* ; Mannhaupt, G. ; Mauceli, E.* ; Mewes, H.-W. ; Mitterbauer, R.* ; Muehlbauer, G.* ; Münsterkötter, M. ; Nelson, D.* ; O'Donnell, K.* ; Ouellet, T.* ; Qi, W.* ; Quesneville, H.* ; Roncero, M.I.* ; Seong, K.Y.* ; Tetko, I.V. ; Urban, M.* ; Waalwijk, C.* ; Ward, T.J.* ; Yao, J.* ; Birren, B.W.* ; Kistler, H.C.*

The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.

Science 317, 1400-1402 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Genome wide association, genetic epidemiology, gene mapping, biobanking, genetic and environmental factors for complex disorders
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 317, Issue: 5843, Pages: 1400-1402 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)