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Cuomo, C.A.* ; Güldener, U. ; Xu, J.R.* ; Trail, F.* ; Turgeon, B.G.* ; Di, Pietro, A.* ; Walton, J.D.* ; Ma, L.J.* ; Baker, S.E.* ; Rep, M.* ; Adam, G.* ; Antoniw, J.* ; Baldwin, T.* ; Calvo, S.* ; Chang, Y.L.* ; Decaprio, D.* ; Gale, L.R.* ; Gnerre, S.* ; Goswami, R.S.* ; Hammond-Kosack, K.* ; Harris, L.J.* ; Hilburn, K.* ; Kennell, JC.* ; Kroken, S.* ; Magnuson, J.K.* ; Mannhaupt, G. ; Mauceli, E.* ; Mewes, H.-W. ; Mitterbauer, R.* ; Muehlbauer, G.* ; Münsterkötter, M. ; Nelson, D.* ; O'Donnell, K.* ; Ouellet, T.* ; Qi, W.* ; Quesneville, H.* ; Roncero, M.I.* ; Seong, K.Y.* ; Tetko, I.V. ; Urban, M.* ; Waalwijk, C.* ; Ward, T.J.* ; Yao, J.* ; Birren, B.W.* ; Kistler, H.C.*

The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.

Science 317, 1400-1402 (2007)
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We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome wide association, genetic epidemiology, gene mapping, biobanking, genetic and environmental factors for complex disorders
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 317, Issue: 5843, Pages: 1400-1402 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Computational Biology (ICB)
Institute of Structural Biology (STB)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
30205 - Bioengineering and Digital Health
30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503700-001
G-503891-001
G-503000-001
DOI 10.1126/science.1143708
Scopus ID 34548669353
Erfassungsdatum 2007-09-21
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