PuSH - Publication Server of Helmholtz Zentrum München: Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells.

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Betz, H.

Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells.

Biochem. Biophys. Res. Commun. 72, 114-120 (1976)

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Open Access Green as soon as Postprint is submitted to ZB.

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In exponentially growing cells of Saccharomyces, cerevisiae, cycloheximide stimulated intracellular protein degradation to the same extent as did starvation for required amino acids. By using inhibitors of macromolecular synthesis and temperature-sensitive mutants defective in different steps of RNA and protein synthesis it could be demonstrated, that this stimulation of protein degradation was directly related to the inhibition of protein synthesis per se, but not connected to the cessation of ribosomal RNA synthesis or to the inhibition of cell growth.

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