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Betz, H.

Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells.

Biochem. Biophys. Res. Commun. 72, 114-120 (1976)

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Open Access Green as soon as Postprint is submitted to ZB.

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In exponentially growing cells of Saccharomyces, cerevisiae, cycloheximide stimulated intracellular protein degradation to the same extent as did starvation for required amino acids. By using inhibitors of macromolecular synthesis and temperature-sensitive mutants defective in different steps of RNA and protein synthesis it could be demonstrated, that this stimulation of protein degradation was directly related to the inhibition of protein synthesis per se, but not connected to the cessation of ribosomal RNA synthesis or to the inhibition of cell growth.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 0006-291X

e-ISSN 1090-2104

Journal Biochemical and Biophysical Research Communications

Quellenangaben Volume: 72, Issue: 1, Pages: 114-120

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institut für Biochemie