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Pockley, A.G.* ; Henderson, B.* ; Multhoff, G.

Extracellular cell stress proteins as biomarkers of human disease.

Biochem. Soc. Trans. 42, 1744-1751 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Biomarker ; Cancer ; Cell Stress Protein ; Enzyme Immunoassay ; Heat-shock Protein ; Molecular Chaperone
ISSN (print) / ISBN 0300-5127
e-ISSN 1470-8752
Quellenangaben Volume: 42, Issue: 6, Pages: 1744-1751 Article Number: , Supplement: ,
Publisher Portland Press
Non-patent literature Publications
Reviewing status Peer reviewed