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Open Access Green as soon as Postprint is submitted to ZB.
Extracellular cell stress proteins as biomarkers of human disease.
Biochem. Soc. Trans. 42, 1744-1751 (2014)
Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Biomarker ; Cancer ; Cell Stress Protein ; Enzyme Immunoassay ; Heat-shock Protein ; Molecular Chaperone
ISSN (print) / ISBN
0300-5127
e-ISSN
1470-8752
Journal
Biochemical Society Transactions
Quellenangaben
Volume: 42,
Issue: 6,
Pages: 1744-1751
Publisher
Portland Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Innate Immunity in Tumor Biology (IBMI-KTB)