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Bongaerts, B.W.* ; Ziegler, D.* ; Shaw, J.E.* ; Heier, M. ; Kowall, B.* ; Herder, C.* ; Roden, M.* ; Peters, A. ; Meisinger, C. ; Rathmann, W.*

A clinical screening score for diabetic polyneuropathy: KORA F4 and AusDiab studies.

J. Diab. Complic. 29, 44-49 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS: Since screening for distal sensorimotor polyneuropathy (DSPN) in individuals with diabetes is being underused, our aim was to develop a clinical screening score for identifying individuals with DSPN. METHODS: All participants with type 2 diabetes and aged 61-82 years from the German population-based KORA F4 Study (n=177) and the Australian population-based AusDiab Study (n=244) were combined into one study sample. Risk indicators of DSPN were identified and entered into a stepwise model-selection procedure, constructing two consecutive scores with increasing complexity (a base and clinical model). RESULTS: The prevalence of DSPN was 18.2% (95% confidence interval (CI): 14.7-22.3). The base model comprised age (years), height (cm), weight (kg), pain or discomfort in the feet and/or legs (yes/no), and duration of diabetes (years), yielding an area under the receiver operating characteristics curve (AUC) of 0.80 (95% CI: 0.76-0.85). The clinical model additionally included diastolic blood pressure (mmHg) and serum creatinine levels (mmol/l). The AUC increased only marginally to 0.82 (0.77-0.87) (p for AUC comparison=0.188). The internal validation of the scores produced similar AUCs. CONCLUSIONS: The screening scores developed in this study are a simple tool to differentiate between a high and low likelihood of having DSPN among individuals with type 2 diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Australia ; Diabetes Mellitus ; Distal Sensorimotor Polyneuropathy ; Epidemiology ; Germany ; Screening Score; Peripheral Neuropathy; Australian Population; Foot Complications; Risk; Care; Association; Prevalence; Threshold; Physician
ISSN (print) / ISBN 1056-8727
e-ISSN 1056-8727
Journal Journal of Diabetes and its Complications
Quellenangaben Volume: 29, Issue: 1, Pages: 44-49 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
German Center for Diabetes Reseach (DZD)