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Avci, D.* ; Fuchs, S.* ; Schrul, B.* ; Fukumori, A.* ; Breker, M.* ; Frumkin, I.* ; Chen, C.Y.* ; Biniossek, M.L.* ; Kremmer, E. ; Schilling, O.* ; Steiner, H.* ; Schuldiner, M.* ; Lemberg, M.K.*

The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

Mol. Cell 56, 630-640 (2014)
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Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces cerevisiae encodes a homolog that we named yeast presenilin fold 1 (Ypf1), which we verify to be an SPP-type protease that localizes to the endoplasmic reticulum (ER). Our work shows that Ypf1 functionally interacts with the ER-associated degradation (ERAD) factors Dfm1 and Doa10 to regulate the abundance of nutrient transporters by degradation. We demonstrate how this noncanonical branch of the ERAD pathway, which we termed "ERAD regulatory" (ERAD-R), responds to ligand-mediated sensing as a trigger. More generally, we show that Ypf1-mediated posttranslational regulation of plasma membrane transporters is indispensible for early sensing and adaptation to nutrient depletion. The combination of systematic analysis alongside mechanistic details uncovers a broad role of intramembrane proteolysis in regulating secretome dynamics.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1097-2765
e-ISSN 1097-4164
Journal Molecular Cell
Quellenangaben Volume: 56, Issue: 5, Pages: 630-640 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501793-001
PubMed ID 25454947
DOI 10.1016/j.molcel.2014.10.012
WOS ID WOS:000346653300005
Scopus ID 84919466648
Erfassungsdatum 2014-12-04
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