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Open Access Green as soon as Postprint is submitted to ZB.
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.
J. Nutr. Biochem. 26, 75-81 (2015)
DJ-1 constitutes a ubiquitously expressed, oxidative stress-responsive protein with multiple functions. DJ-1 emerged as a candidate from our previous proteome analysis investigating alterations in the hypothalamus in three mouse strains differing in their susceptibility to diet-induced obesity (DIO). Validation studies demonstrated a high-fat diet (HFD)-induced shift in the DJ-1 isoform pattern in the hypothalamus and several other tissues of mice. Others found HFD-induced alterations in DJ-1 protein abundance in adipose tissue and pancreatic islets in wild-type rodents. Here, we investigated the gene-diet interaction by challenging Dj-1(-/-) mice with a HFD. We demonstrate that the development of diet-induced obesity (DIO) Dj-1(-/-) mice is according to wild-type mice with the exception of transient higher gains in fat mass at the expense of lean mass after 14 weeks of feeding.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dj-1 ; Diet-induced Obesity ; High-fat Diet ; Mice ; Neurodegeneration ; Park7
ISSN (print) / ISBN
0955-2863
e-ISSN
0955-2863
Quellenangaben
Volume: 26,
Issue: 1,
Pages: 75-81
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed