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Schuster, F.R.* ; Stanglmaier, M.* ; Woessmann, W.* ; Winkler, B.* ; Siepermann, M.* ; Meisel, R.* ; Schlegel, P.G.* ; Hess J.* ; Lindhofer, H.G.* ; Borkhardt, A.* ; Buhmann, R.

Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies.

Br. J. Haematol. 169, 90-102 (2015)
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Open Access Green as soon as Postprint is submitted to ZB.
Summary: Children with B cell malignancies refractory to standard therapy are known to have a poor prognosis and very limited treatment options. Here, we report on the treatment and follow-up of ten patients diagnosed with relapsed or refractory mature B-cell Non Hodgkin Lymphoma (B-NHL), Burkitt leukaemia (B-AL) or pre B-acute lymphoblastic leukaemia (pre B-ALL). All children were treated with FBTA05 (now designated Lymphomun), an anti-CD3 x anti-CD20 trifunctional bispecific antibody (trAb) in compassionate use. Within individual treatment schedules, Lymphomun was applied (a) after allogeneic stem cell transplantation (allo-SCT, n = 6) to induce sustained long-term remission, or (b) stand alone prior to subsequent chemotherapy to eradicate residual disease before allo-SCT (n = 4). Nine of ten children displayed a clinical response: three stable diseases (SD), one partial remission (PR) and five induced or sustained complete remissions (CR). Five of these nine responders died during follow-up. The other patients still maintain CR with a current overall survival of 874-1424 days (median: 1150 days). In conclusion, despite the dismal clinical prognosis of children refractory to standard therapy, immunotherapy with Lymphomun resulted in a favourable clinical outcome in this cohort of refractory paediatric patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Anti-cd20 X Anti-cd3 ; B-cell Malignancies ; Bispecific Antibody ; Children ; Immunotherapy; Non-hodgkin-lymphoma; Acute-lymphoblastic-leukemia; Lasting Antitumor Immunity; Central-nervous-system; Bispecific Antibody; Allogeneic Lymphocytes; Accessory Cells; Cancer-therapy; Phase Ii/iii; T-cells
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0007-1048
e-ISSN 1365-2141
Journal British Journal of Haematology
Quellenangaben Volume: 169, Issue: 1, Pages: 90-102 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) CCG Hematopoetic Cell Transplants (IMI-KHZ)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-520300-001
DOI 10.1111/bjh.13242
WOS ID WOS:000351446400012
Scopus ID 84925114367
Scopus ID 84919665118
Erfassungsdatum 2015-01-01
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