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Open Access Green as soon as Postprint is submitted to ZB.
The CatSper channel controls chemosensation in sea urchin sperm.
EMBO J. 34, 379-392 (2015)
Sperm guidance is controlled by chemical and physical cues. In many species, Ca(2+) bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca(2+) bursts. The underlying Ca(2+) channel and its mechanisms of activation are unknown. Here, we identify CatSper Ca(2+) channels in the flagellum of A. punctulata sperm. We show that CatSper mediates the chemoattractant-evoked Ca(2+) influx and controls chemotactic steering; a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca(2+) bursts. Our results reveal intriguing phylogenetic commonalities but also variations between marine invertebrates and mammals regarding the function and control of CatSper. The variations probably reflect functional and mechanistic adaptations that evolved during the transition from external to internal fertilization.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ca2+ Signaling ; Catsper ; Chemotaxis ; Sperm; Egg Peptide Speract; Receptor-mediated Activation; Intracellular Ph; Male-fertility; Acrosome Reaction; Ca2+ Channel; Transmembrane Protein; Mammalian Spermatozoa; Mouse Spermatozoa; Guanylate-cyclase
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Journal
EMBO Journal, The
Quellenangaben
Volume: 34,
Issue: 3,
Pages: 379-392
Publisher
Wiley
Publishing Place
Heidelberg, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)