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Gottschalk, S. ; Fehm, T. ; Dean-Ben, X.L. ; Razansky, D.

Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography.

J. Cereb. Blood Flow Metab. 35, 531-535 (2015)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Current functional neuroimaging methods are not adequate for high-resolution whole-brain visualization of neural activity in real time. Here, we show imaging of fast hemodynamic changes in deep mouse brain using fully noninvasive acquisition of five-dimensional optoacoustic data from animals subjected to oxygenation stress. Multispectral video-rate acquisition of three-dimensional tomographic data enables simultaneous label-free assessment of multiple brain hemodynamic parameters, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin, in real time. The unprecedented results indicate that the proposed methodology may serve as a powerful complementary, and potentially superior, method for functional neuroimaging studies in rodents.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cerebral Hemodynamics ; Functional Neuroimaging ; Neuroimaging ; Optoacoustic/photoacoustic Tomography ; Real Time; In-vivo; Blood-flow; Metabolism; Microscopy; Vasculature; Oxygenation; Dynamics
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0271-678X
e-ISSN 1559-7016
Journal Journal of Cerebral Blood Flow & Metabolism
Quellenangaben Volume: 35, Issue: 4, Pages: 531-535 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505590-001
PubMed ID 25586142
DOI 10.1038/jcbfm.2014.249
WOS ID WOS:000352027900002
Scopus ID 84926528110
Scopus ID 84922606972
Erfassungsdatum 2015-01-16
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