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Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography.
J. Cereb. Blood Flow Metab. 35, 531-535 (2015)
Current functional neuroimaging methods are not adequate for high-resolution whole-brain visualization of neural activity in real time. Here, we show imaging of fast hemodynamic changes in deep mouse brain using fully noninvasive acquisition of five-dimensional optoacoustic data from animals subjected to oxygenation stress. Multispectral video-rate acquisition of three-dimensional tomographic data enables simultaneous label-free assessment of multiple brain hemodynamic parameters, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin, in real time. The unprecedented results indicate that the proposed methodology may serve as a powerful complementary, and potentially superior, method for functional neuroimaging studies in rodents.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cerebral Hemodynamics ; Functional Neuroimaging ; Neuroimaging ; Optoacoustic/photoacoustic Tomography ; Real Time; In-vivo; Blood-flow; Metabolism; Microscopy; Vasculature; Oxygenation; Dynamics
ISSN (print) / ISBN
0271-678X
e-ISSN
1559-7016
Quellenangaben
Volume: 35,
Issue: 4,
Pages: 531-535
Publisher
Nature Publishing Group
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)