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Bézière, N. ; Ntziachristos, V.

Optoacoustic imaging of naphthalocyanine: Potential for contrast enhancement and therapy monitoring.

J. Nucl. Med. 56, 323-328 (2015)
Postprint DOI PMC
Open Access Green
We investigated in vitro and in vivo the optoacoustic responses of a silicon naphthalocyanine (SiNc), considered herein as a reporter molecule for optoacoustic imaging, elucidating its efficiency for optoacoustic (photoacoustic) signal generation and examined the in vivo performance achieved. METHODS: SiNc solutions were prepared using Cremophor E.L. in water and evaluated for light absorbing and photoacoustic contrast generating properties. Photostability and singlet oxygen generation were investigated under pulsed laser illumination and validated using photoabsorbance. HT-29 mice tumor models were used to assess the biodistribution of the compound and its performance as an optoacoustic contrast agent in vivo. RESULTS: SiNc was found to generate superior optoacoustic signals compared to the commonly used Indocyanine Green (ICG). Multispectral optoacoustic tomography (MSOT) of mouse tumors efficiently resolved the biodistribution of SiNc and the underlying perfusion parameters in vivo. In addition, we demonstrate how light-triggered SiNc reactions with molecular oxygen can be potentially sensed and discuss the relation of these measurements to the biochemical process involved in photothermal treatment. CONCLUSION: SiNc appears to be a promising family of contrast agent for optoacoustic imaging. Further development possibilities promise to expand its use in purely contrast generation settings, as well as its photodynamic therapy application.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Animal Imaging ; Molecular Imaging ; Naphthalocyanine ; Oncology: General ; Optical ; Imaging ; Optoacoustic ; Photoacoustic ; Photodynamic Therapy; Photodynamic Therapy; Phthalocyanine; Tomography; 2,3-naphthalocyanine; Derivatives; Model
ISSN (print) / ISBN 0161-5505
e-ISSN 1535-5667
Journal Journal of Nuclear Medicine
Quellenangaben Volume: 56, Issue: 2, Pages: 323-328 Article Number: , Supplement: ,
Publisher Society of Nuclear Medicine and Molecular Imaging
Publishing Place Reston
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)