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Koch, M.* ; Baurecht, H.* ; Ried, J.S. ; Rodriguez, E.* ; Schlesinger, S.* ; Volks, N.* ; Gieger, C. ; Rückert, I.-M. ; Heinrich, L.* ; Willenborg, C.* ; Smith, C.* ; Peters, A. ; Thorand, B. ; Koenig, W.* ; Lamina, C.* ; Jansen, H.* ; Kronenberg, F.* ; Seissler, J.* ; Thiery, J.* ; Rathmann, W.* ; Schunkert, H.* ; Erdmann, J.* ; Barker, J.* ; Nair, R.P.* ; Tsoi, L.C.* ; Elder, J.T.* ; Mrowietz, U.* ; Weichenthal, M.* ; Mucha, S.* ; Schreiber, S.* ; Franke, A.* ; Schmitt, J.* ; Lieb, W.* ; Weidinger, S.*

Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures.

J. Invest. Dermatol. 135, 1283-1293 (2015)
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Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4.185) and a prospective cohort of German Health Insurance beneficiaries (n=1.811.098). A potential genetic overlap was explored using genome-wide data from >22.000 coronary artery disease (CAD) and >4.000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3.717 controls. Controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odd's ratio OR=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26, 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk RR=1.11; 95%CI=1.08-1.14) and MI (RR=1.14; 95%CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the MHC, there was no evidence for genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Coronary-artery-disease; Major Histocompatibility Complex; Cardiovascular-disease; Susceptibility Loci; Metabolic Syndrome; Risk-factors; Metaanalysis; Prevalence; Atherosclerosis
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0022-202X
e-ISSN 1523-1747
Journal Journal of Investigative Dermatology, The
Quellenangaben Volume: 135, Issue: 5, Pages: 1283-1293 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
CCG Nutrigenomics and Type 2 Diabetes (KKG-KDN)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-504091-004
G-504000-002
G-521500-002
G-501900-701
G-504000-006
PubMed ID 25599394
DOI 10.1038/jid.2015.8
WOS ID WOS:000353011000015
Scopus ID 84928419406
Erfassungsdatum 2015-01-21
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