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Kirsch, F.

A systematic review of quality and cost-effectiveness derived from Markov models evaluating smoking cessation interventions in patients with chronic obstructive pulmonary disease.

Expert Rev. Pharmacoecon. Outcomes Res. 15, 301-316 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Smoking cessation is the only strategy that has shown a lasting reduction in the decline of lung function in patients with chronic obstructive pulmonary disease. This study aims to evaluate the cost-effectiveness of smoking cessation interventions in patients with chronic obstructive pulmonary disease, to assess the quality of the Markov models and to estimate the consequences of model structure and input data on cost-effectiveness. A systematic literature search was conducted in PubMed, Embase, BusinessSourceComplete and Econlit on June 11, 2014. Data were extracted, and costs were inflated. Model quality was evaluated by a quality appraisal, and results were interpreted. Ten studies met the inclusion criteria. The results varied widely from cost savings to additional costs of €17,004 per quality adjusted life year. The models scored best in the category structure, followed by data and consistency. The quality of the models seems to rise over time, and regarding the results there is no economic reason to refuse the reimbursement of any smoking cessation intervention.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Markov Model ; Chronic Obstructive Pulmonary Disease ; Cost–effectiveness ; Review ; Smoking Cessation; Health Technology-assessment; Dynamic Population-model; Economic-evaluation; Lung Health; Copd; Varenicline; Simulation; Guidelines; Countries; Germany
ISSN (print) / ISBN 1473-7167
e-ISSN 1744-8379
Journal Expert Review of Pharmacoeconomics and Outcomes Research
Quellenangaben Volume: 15, Issue: 2, Pages: 301-316 Article Number: , Supplement: ,
Publisher Taylor & Francis
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
German Center for Lung Research (DZL)