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Open Access Green as soon as Postprint is submitted to ZB.
NOS2 and CCL27: Clinical implications for psoriasis and eczema diagnosis and management.
Expert Rev. Clin. Immunol. 11, 167-169 (2015)
Chronic inflammatory skin diseases such as psoriasis and eczema are a major medical challenge. Development of highly specific therapies for both conditions is opposed by the lack of translation of basic knowledge into biomarkers for clinical use. Furthermore, to distinguish psoriasis from eczema might be difficult occasionally, but specific and costly therapies would not be efficient in misdiagnosed patients. In the era of high-throughput 'omics'-technologies, comparing the molecular signature of psoriasis and eczema is a promising approach to gain insight into their complex pathogeneses and develop new diagnostic and therapeutic strategies. Investigating patients affected by both psoriasis and eczema simultaneously, we recently constructed a disease classifier consisting of only two genes (NOS2 and CCL27) that reliably predicts the correct diagnosis even in clinically unclear cases. When such easy-to-handle approaches are combined with individual therapeutic response, we might reach the ultimate goal of personalized medicine in inflammatory skin diseases in near future.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Atopic Dermatitis/eczema ; Ccl27 ; Diagnosis ; Diseases Classifier ; Eczema ; Inflammatory Skin Disease ; Molecular Signature ; Nos2 ; Psoriasis; Nitric-oxide Synthase; Atopic-dermatitis; Tnf-alpha; Skin; Differentiation; Keratinocytes; Expression; Arginase; Cells; Th1
ISSN (print) / ISBN
1744-666X
Quellenangaben
Volume: 11,
Issue: 2,
Pages: 167-169
Publisher
Expert Reviews
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)