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Meiners, S. ; Eickelberg, O. ; Königshoff, M.

Hallmarks of the ageing lung.

Eur. Respir. J. 45, 807-827 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Ageing is the main risk factor for major non-communicable chronic lung diseases, including chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary fibrosis. While the prevalence of these diseases continually increases with age, their respective incidence peaks at different times during the lifespan, suggesting specific effects of ageing on the onset and/or pathogenesis of chronic obstructive pulmonary disease, lung cancer and idiopathic pulmonary fibrosis. Recently, the nine hallmarks of ageing have been defined as cell-autonomous and non-autonomous pathways involved in ageing. Here, we review the available evidence for the involvement of each of these hallmarks in the pathogenesis of chronic obstructive pulmonary disease, lung cancer, or idiopathic pulmonary fibrosis. Importantly, we propose an additional hallmark, "dysregulation of the extracellular matrix", which we argue acts as a crucial modifier of cell-autonomous changes and functions, and as a key feature of the above-mentioned lung diseases.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Idiopathic Pulmonary-fibrosis; Endoplasmic-reticulum Stress; Unfolded-protein-response; Alveolar Epithelial-cells; Microsatellite Dna Instability; Endothelial Progenitor Cells; Ubiquitin-proteasome System; Mesenchymal Stem-cells; Age-related Disease; Growth-factor-beta
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 45, Issue: 3, Pages: 807-827 Article Number: , Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)