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Open Access Green as soon as Postprint is submitted to ZB.
Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?
Int. J. Biochem. Cell Biol. 63, 16-20 (2015)
For more than 50 years, reactive oxygen species have been considered as harmful agents, which can attack proteins, lipids or nucleic acids. In order to deal with reactive oxygen species, there is a sophisticated system developed in mitochondria to prevent possible damage. Indeed, increased reactive oxygen species levels contribute to pathomechanisms in several human diseases, either by its impaired defense system or increased production of reactive oxygen species. However, in the last two decades, the importance of reactive oxygen species in many cellular signaling pathways has been unraveled. Homeostatic levels were shown to be necessary for correct differentiation during embryonic expansion of stem cells. Although the mechanism is still not fully understood, we cannot only regard reactive oxygen species as a toxic by-product of mitochondrial respiration anymore.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ros Scavenging ; Ros Signalization ; Reactive Oxygen Species; Protein-tyrosine Phosphatases; Hydrogen-peroxide; Redox Regulation; Complex Iii; Superoxide; Dehydrogenase; Thioredoxin; Inactivation; Generation; Apoptosis
ISSN (print) / ISBN
1357-2725
e-ISSN
1878-5875
Quellenangaben
Volume: 63,
Pages: 16-20
Publisher
Elsevier
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)