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Open Access Green as soon as Postprint is submitted to ZB.
Comparison of the automated KRYPTOR chromogranin A assay with the DAKO ELISA.
Clin. Lab. 60, 2103-2106 (2014)
Background: Currently available assays for the widely used marker for neuroendocrine tumors chromogranin A have a weak comparability, involve manual work, and require batch processing of the samples. In this study, we evaluated the automated chromogranin A KRYPTOR assay compared with the widely used DAKO ELISA. Methods: 83 samples were measured with the DAKO ELISA (EDTA plasma) and the KRYPTOR assay (serum), since different sample materials are recommended. Furthermore, different sample materials were compared. Results: The results between the two assays were highly correlated KRYPTOR serum (ng/mL) = 2.887 ELISA EDTA (U/L) + 5.028; r = 0.99). The inter-assay variation for the KRYPTOR assay was determined as 5.56% at low (95 ng/mL; n = 34) and 6.21% at high (530 ng/mL; n = 33) chromogranin A concentrations. EDTA plasma samples revealed significantly lower results than serum in the KRYPTOR assays and could not be used. Conclusions: In conclusion, the new chromogranin A KRYPTOR assay is fast, reliable, and compares well to an established test after adaptation of sample material and reported units.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chromogranin A ; Assay ; Kryptor ; Tumor Marker; Tumors
ISSN (print) / ISBN
1433-6510
Journal
Clinical Laboratory
Quellenangaben
Volume: 60,
Issue: 12,
Pages: 2103-2106
Publisher
Clinical Laboratory Publ.
Publishing Place
Mainz
Non-patent literature
Publications
Reviewing status
Peer reviewed